Nexgard vs Credelio: Unraveling the Best Flea and Tick Protection


In the realm of pet health, ensuring optimal protection against fleas and ticks is paramount. As pet owners, we’re always seeking the best possible products to maintain our furry friends’ wellbeing. Among the myriad of flea and tick protection options, two brands, Nexgard and Credelio, have emerged as front runners. But how do these products stack up against each other? Today, we explore the efficacy, safety, and reliability of Nexgard and Credelio, providing you with insights to help you make an informed decision.

ManufacturerBoehringer IngelheimElanco
Active IngredientAfoxolanerLotilaner
EfficacyKills 100% fleas within 24 hoursKills 100% fleas within 12 hours
Tick ProtectionLone Star, Black-legged, American Dog, Brown DogLone Star, American Dog, Black-legged, Brown Dog
Lyme Disease ProtectionYes (First FDA-approved for this use)No
Approved AgeAt least 8 weeks oldAt least 8 weeks old
Minimum WeightMore than 4 poundsMore than 4.4 pounds
Side EffectsVomiting, itching, lethargy, diarrhea, lack of appetiteWeight loss, increased BUN, polyuria, diarrhea
FormChewable tabletChewable tablet
Nexgard vs Credelio

Nexgard: Your Pet’s Shield Against Fleas and Ticks

Nexgard, a product by Boehringer Ingelheim, has carved its place as a trusted solution in the pet health industry. Its active ingredient, afoxolaner, works effectively to kill fleas and ticks by interfering with the nervous system of these pests, causing death.


Studies have demonstrated that Nexgard kills 100% of fleas within 24 hours for a full month. It also offers protection against ticks, including the Lone Star tick, Black-legged tick, American Dog tick, and Brown dog tick. Moreover, Nexgard is the first FDA-approved product that prevents infections that cause Lyme disease.


Nexgard is suitable for dogs that are at least eight weeks old and weigh more than 4 pounds. Side effects are rare but may include vomiting, itching, lethargy, diarrhea, and lack of appetite. Always consult with a vet before starting any new medication for your pet.

Credelio: Fortifying Your Pet’s Defenses

Manufactured by Elanco, Credelio is another popular choice among pet owners. Its active ingredient, lotilaner, effectively interrupts the nerve impulses in fleas and ticks, leading to their death.


Credelio has shown impressive results, killing 100% of fleas within 12 hours for an entire month. It’s also effective against ticks, including the Lone Star tick, American Dog tick, Black-legged tick, and Brown dog tick.


Credelio is approved for puppies and dogs that are at least 8 weeks old and weigh 4.4 pounds or more. The potential side effects include weight loss, elevated blood urea nitrogen (BUN), polyuria, and diarrhea. As with any medication, it is vital to discuss these aspects with your vet before administering Credelio.

Nexgard vs Credelio: The Showdown

When choosing between Nexgard and Credelio, it’s important to consider your pet’s specific needs, the product’s efficacy, and any potential side effects. Both products offer a high level of efficacy against fleas and ticks. However, Nexgard has an edge as it is the first product approved to prevent Lyme disease.

In terms of safety, both have potential side effects, and it’s critical to consult your vet before making a decision.

While each pet is unique, being equipped with accurate information about Nexgard and Credelio will guide you towards a choice that best fits your pet’s health requirements.

Wrapping Up

When it comes to safeguarding your pets from fleas and ticks, both Nexgard and Credelio emerge as powerful contenders. Both offer a high degree of protection, with quick action and long-lasting effects. Your final choice, however, should consider your pet’s individual health status, lifestyle, and your vet’s advice. With these guidelines in mind, you can ensure that your four-legged friend stays safe and happy!

Always consult with your vet or a trained pet healthcare professional for the best course of action for your pet’s health.

Potential Side Effects: A Closer Look

When choosing between Nexgard and Credelio, it’s worth delving into the potential side effects a little further. While both medications have been thoroughly tested and approved for use, it’s always wise to keep an eye on your pet after administering any new treatment.

In rare cases, Nexgard may cause digestive upset, skin irritations, or lethargy. On the other hand, Credelio might lead to weight loss, increased thirst and urination, and occasional digestive upset.

Most pets tolerate both medications very well, and these side effects are rare. However, if your pet has any pre-existing conditions or is sensitive to medications, discuss this with your vet. They can provide a tailored treatment plan that keeps your pet’s specific needs in mind.

Real World Experience

Anecdotal evidence from pet owners suggests that both Nexgard and Credelio are effective and easy to administer, thanks to their tasty, chewable tablet forms. Dogs seem to accept the tablets as treats, making the process hassle-free.

Making an Informed Decision

Deciding between Nexgard and Credelio may come down to individual factors like your pet’s age, weight, health status, and lifestyle. Both products are highly effective and offer broad protection against a range of ticks and fleas, but consulting your vet will ensure you make the most informed choice.

Ultimately, the health and happiness of our pets are our primary concerns. By carefully considering the benefits and potential drawbacks of each medication, we can ensure they receive the best possible care. Remember, the most effective flea and tick control strategy includes regular vet check-ups, maintaining a clean environment, and keeping up with preventative treatments.

In conclusion, Nexgard and Credelio both offer reliable protection against harmful pests, ensuring our furry friends can enjoy their adventures worry-free. As a responsible pet owner, take time to understand these products, consult with your vet, and make a choice that suits your pet the best. Their health and wellbeing are worth it!

Disclaimer: This blog provides general information and discussion about pet health and related subjects. The content provided in this blog and any linked materials is not intended and should not be construed as medical advice. If the reader or any other person has a veterinary medical concern, he or she should consult with a properly licensed veterinarian or other pet health care provider.


Q1: What are the key differences between Nexgard and Credelio?

A1: While both Nexgard and Credelio are effective against fleas and ticks, Nexgard is the first FDA-approved product for preventing infections that cause Lyme disease. The time taken for each medication to kill 100% of fleas also varies – Nexgard takes 24 hours, while Credelio takes 12 hours.

Q2: Are there any side effects of Nexgard and Credelio?

A2: Both Nexgard and Credelio may have potential side effects. Nexgard’s side effects may include vomiting, itching, lethargy, diarrhea, and lack of appetite. On the other hand, Credelio’s potential side effects might include weight loss, increased BUN, polyuria, and diarrhea. However, these are rare, and it’s important to consult with a vet before starting any new medication.

Q3: How quickly do Nexgard and Credelio work?

A3: Both Nexgard and Credelio work quickly to eliminate fleas and ticks. Nexgard kills 100% of fleas within 24 hours, while Credelio eliminates 100% of fleas within just 12 hours.

Q4: Can I use Nexgard or Credelio for my puppy?

A4: Both Nexgard and Credelio are safe for puppies that are at least 8 weeks old. Nexgard is suitable for puppies weighing more than 4 pounds, while Credelio can be given to those weighing 4.4 pounds or more.

Q5: How do I choose between Nexgard and Credelio?

A5: Choosing between Nexgard and Credelio should be based on your pet’s specific needs, lifestyle, and the product’s efficacy and safety profile. Consulting your vet is a crucial step in making this decision.

Q6: Are Nexgard and Credelio chewable?

A6: Yes, both Nexgard and Credelio come in the form of a tasty, chewable tablet, making administration hassle-free.

Q7: Can I use Nexgard or Credelio for my cat?

A7: Nexgard is specifically for dogs, while Credelio has products for both dogs and cats. However, always consult your vet before starting any new medication for your pet.

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